Article
Cellular ras gene activity is required for full neoplastic transformation by polyomavirus.
Journal of virology - 1 Oct 1991
Raptis L, Marcellus R, Corbley M J, Krook A, Whitfield J, Anderson S K, Haliotis T
Abstract excerpt
To investigate the role of ras gene activity in cellular transformation by polyomavirus, murine C3H10T1/2 cells were rendered ras deficient by transfection with an antisense ras gene construct. Ras deficiency resulted in a partial suppression of the polyomavirus-induced transformed phenotype. The...
Topics
- Animals
- Antigens, Polyomavirus Transforming
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- Chromosome Deletion
- Cloning, Molecular
- Genes, ras
- Introns
- Kinetics
- Mice
- Mice, Inbred C3H
- Phenotype
- Polyomavirus
- Protein Kinase C
- Proto-Oncogene Proteins p21(ras)
- Transcription, Genetic
- Transfection