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Article

Cellular ras gene activity is required for full neoplastic transformation by polyomavirus.

Journal of virology - 1 Oct 1991

Raptis L, Marcellus R, Corbley M J, Krook A, Whitfield J, Anderson S K, Haliotis T

Abstract excerpt

To investigate the role of ras gene activity in cellular transformation by polyomavirus, murine C3H10T1/2 cells were rendered ras deficient by transfection with an antisense ras gene construct. Ras deficiency resulted in a partial suppression of the polyomavirus-induced transformed phenotype. The production of viral middle T antigen and its association with pp60c-src, increased membrane-associated protein kinase...

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Identifiers

PMID: 1654439
DOI: 10.1128/JVI.65.10.5203-5210.1991
PMCID: PMC248998

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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