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Article

Independent contributions of polyomavirus middle T and small T to the regulation of early and late gene expression and DNA replication.

Journal of virology - 1 Aug 2006

Chen Li, Wang Xiaoyu, Fluck Michele M

Abstract excerpt

We previously showed that murine polyomavirus mutants that lack both middle T (MT) and small T (ST) functions have a severe pleiotropic defect in early and late viral gene expression as well as genome amplification. The respective contribution of MT and ST to this phenotype was unclear. This work separates the roles of MT and ST in both permissive mouse cells and nonpermissive rat cells. It demonstrates for the...

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Source

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Identifiers

PMID: 16840310
DOI: 10.1128/JVI.00679-06
PMCID: PMC1563708

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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