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Article

Separation of immortalization from tumor induction with polyoma large T mutants that fail to bind the retinoblastoma gene product.

Oncogene - 1 Oct 1992

Freund R, Bronson R T, Benjamin T L

Abstract excerpt

The mouse polyomavirus encodes a tumor-suppressor gene inactivator in its large T protein and a proto-oncogene activator in its middle T protein. We have used site-directed mutagenesis to selectively inactivate the former function without affecting the latter. Two mutant viruses were constructed to encode altered large T proteins that fail to bind the retinoblastoma tumor-suppressor gene product pRB, along with...

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PMID: 1328987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Separation of immortalization from tumor induction with polyoma large T mutants that fail to bind the retinoblastoma gene product.PMID 1328987Read ↗

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