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Article

Studies of partially transforming polyomavirus mutants establish a role for phosphatidylinositol 3-kinase in activation of pp70 S6 kinase.

Molecular and cellular biology - 1 Jun 1996

Dahl J, Freund R, Blenis J, Benjamin T L

Abstract excerpt

Infection of mouse fibroblasts by wild-type polyomavirus results in increased phosphorylation of ribosomal protein S6 (D.A. Talmage, J. Blenis, and T.L. Benjamin, Mol. Cell. Biol. 8:2309-2315, 1988). Here we identify pp70 S6 kinase (pp70S6K) as a target for signal transduction events leading from polyomavirus middle tumor antigen (mT). Two partially transforming virus mutants altered in different mT signalling...

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Identifiers

PMID: 8649380
DOI: 10.1128/MCB.16.6.2728
PMCID: PMC231263

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