Article
In vitro studies of cytokine-mediated interactions between malignant glioma and autologous peripheral blood mononuclear cells.
Journal of neurosurgery - 1 Oct 1994
Jachimczak P, Schwulera U, Bogdahn U
Abstract excerpt
The humoral interactions between three malignant glioma early-passage cell cultures and in vitro interleukin (IL)-1 alpha- and IL-2-activated autologous peripheral blood mononuclear cells (PBMC's) were investigated, employing standard and modified (separated by permeable membranes) mixed lymphocyte tumor cell (MLTC) cultures. In modified MLTC's, glioma cells clearly inhibit proliferation of PBMC's (up to 60%),...
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