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Article

Substance P activates responses correlated with tumour growth in human glioma cell lines bearing tachykinin NK1 receptors

18 Dec 1998

Abstract excerpt

The neuropeptide substance P (SP), by stimulating tachykinin NK1 receptors (NK1R), triggers a number of biological responses in human glioma cells which are potentially relevant for tumour growth. First, radioligand binding studies demonstrated the presence of tachykinin NK1R on SNB-19, DBTRG-05 MG and U373 MG, but not on U138 MG and MOG-G-GCM human glioma cell lines. Second, application of SP or neurokinin A...

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PMID: 9888463
DOI: 10.1038/sj.bjc.6690039

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