Article
Glatiramer acetate (copolymer-1)-specific, human T cell lines: cytokine profile and suppression of T cell lines reactive against myelin basic protein.
Neuroscience letters - 11 Aug 2000
Dabbert D, Rösner S, Krämer M, Schöll U, Tumani H, Mäder M, Weber F
Abstract excerpt
Glatiramer acetate (GA), represents an established treatment of relapsing/remitting multiple sclerosis (MS). The mechanisms responsible for the effect of GA are not fully understood. We generated GA-, myelin basic protein (MBP)- and purified protein derivative (PPD)-specific T cell lines from three MS patients and one healthy donor. The GA-specific lines were CD3+, CD4+, CD8- and produced...
Topics
- Cell Division
- Cell Line
- Cytokines
- Glatiramer Acetate
- Humans
- Immunosuppressive Agents
- Multiple Sclerosis, Relapsing-Remitting
- Myelin Basic Protein
- Peptides
- Phenotype
- T-Lymphocytes