Human melanoma-mediated inhibition of autologous CD4+ helper tumor-infiltrating lymphocyte growth in vitro.

doi:10.1002/1097-0142(19920401)69:7<1843::aid-cncr2820690728>3.0.co;2-d

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Article

Human melanoma-mediated inhibition of autologous CD4+ helper tumor-infiltrating lymphocyte growth in vitro.

Cancer - 1 Apr 1992

Darrow T L, Wahab Z, Quinn-Allen M A, Seigler H F

Abstract excerpt

Tumor-infiltrating lymphocytes (TIL) were isolated from a human melanoma metastatic to the abdomen. The TIL were 99% CD3+ and 99% CD4+ and CD8-. They were dependent on interleukin-2 (IL-2) for growth, as measured in a thymidine uptake assay, and were not cytotoxic to autologous or allogeneic mela...

Topics

Biological Factors
CD4 Antigens
Cell Division
Cell Extracts
Humans
Interleukin-2
Kinetics
Lymphocytes, Tumor-Infiltrating
Melanoma
Phenotype
Prostaglandins
T-Lymphocytes, Helper-Inducer
Tumor Cells, Cultured

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