Article
Changes in the immunologic phenotype of human malignant glioma cells after passaging in vitro.
Clinical immunology (Orlando, Fla.) - 1 Jan 2002
Anderson Richard C, Elder James B, Brown Melandee D, Mandigo Christopher E, Parsa Andrew T, Kim Paul D, Senatus Patrick, Anderson David E, Bruce Jeffrey N
Abstract excerpt
Although immunotherapeutic strategies against glioblastomas have been promising both in vitro and in animal models, similar successes have not been realized in human clinical trials. One reason may be that immunotherapeutic strategies are based on prior studies that primarily have used human glioblastoma cell lines passaged in vitro, which may not accurately reflect the in vivo properties of glioblastoma cells....
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