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Article

Effects of cytokines on in vitro growth of tumor-infiltrating lymphocytes obtained from human primary and metastatic liver tumors.

Cancer immunology, immunotherapy : CII - 1 Jan 1991

Shimizu Y, Iwatsuki S, Herberman R B, Whiteside T L

Abstract excerpt

Tumor-infiltrating lymphocytes (TIL) were isolated from 22 human primary and metastatic liver tumors, and expanded in vitro in the presence of either interleukin-2 (IL-2, 100 U/ml) plus tumor necrosis factor alpha (TNF alpha, 1000 U/ml), IL-2 (1000 U/ml) plus IL-4 (1000 U/ml) or IL-2 (1000 U/ml) alone. TIL proliferated in culture in 20/22 cases. Among different cytoline combination, TNF alpha and IL-2 were most...

Topics

Carcinoma, Hepatocellular
Cell Division
Cell Survival
Cells, Cultured
Cytokines
Cytotoxicity, Immunologic
Drug Therapy, Combination
Humans
Interleukin-2
Interleukin-4
Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocyte Activation

Lymphocytes

Lymphocytes, Tumor-Infiltrating

Phenotype

Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 1847844
DOI: 10.1007/BF01789045
PMCID: PMC11038158

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1847844-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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