The effect of transforming growth factor-beta 2-specific phosphorothioate-anti-sense oligodeoxynucleotides in reversing cellular immunosuppression in malignant glioma.

doi:10.3171/jns.1993.78.6.0944

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Article

The effect of transforming growth factor-beta 2-specific phosphorothioate-anti-sense oligodeoxynucleotides in reversing cellular immunosuppression in malignant glioma.

Journal of neurosurgery - 1 Jun 1993

Jachimczak P, Bogdahn U, Schneider J, Behl C, Meixensberger J, Apfel R, Dörries R, Schlingensiepen K H, Brysch W

Abstract excerpt

This in vitro study was aimed at restitution of transforming growth factor (TGF)-beta 2-mediated suppression of T-lymphocyte activation within malignant gliomas. In early-passage tumor cell cultures of two glioblastomas (HTZ-153 and HTZ-209) and one malignant astrocytoma classified as World Healt...

Topics

Antigens, CD
Antigens, Neoplasm
Blotting, Northern
Blotting, Western
Brain Neoplasms
Glioma
Humans
Immunity, Cellular
Immunocompromised Host
Killer Cells, Lymphokine-Activated
Leukocytes, Mononuclear
Oligonucleotides, Antisense
Phenotype

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Neoplasm

T-Lymphocytes, Cytotoxic

Transforming Growth Factor beta

Tumor Cells, Cultured

Source

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Identifiers

PMID: 8487077
DOI: 10.3171/jns.1993.78.6.0944

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8487077-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.