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Article

Synergy between interleukin-2 and prothymosin alpha for the increased generation of cytotoxic T lymphocytes against autologous human carcinomas.

Cancer immunology, immunotherapy : CII - 1 Oct 2000

Voutsas I F, Baxevanis C N, Gritzapis A D, Missitzis I, Stathopoulos G P, Archodakis G, Banis C, Voelter W, Papamichail M

Abstract excerpt

Peripheral blood mononuclear cells (PBMC) from cancer patients were cultured in vitro with irradiated autologous tumor cells isolated from malignant effusions (mixed lymphocyte tumor cultures, MLTC) and low-dose (50 IU/ml) recombinant interleukin-2 (IL-2). The combination of IL-2 and prothymosin alpha (ProTalpha) resulted in a greater PBMC-induced response to the autologous tumor than that brought about by IL-2...

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Identifiers

PMID: 11043852
DOI: 10.1007/s002620000132
PMCID: PMC11037007

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