Article
Human autologous in vitro models of glioma immunogene therapy using B7-2, GM-CSF, and IL12.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques - 1 Aug 2002
Parney Ian F, Farr-Jones Maxine A, Kane Kevin, Chang Lung-Ji, Petruk Kenneth C
Abstract excerpt
BACKGROUND: Cancer immunogene therapy is based on vaccination with radiated, autologous tumor cells transduced with immunostimulatory genes. To help determine an optimal glioma immunogene therapy strategy, we stimulated lymphocytes with autologous human glioma cells transduced with B7-2 (CD86), granulocyte-macrophage colony-stimulating factor (GM-CSF), and/or interleukin-12 (IL12). METHODS: A human glioma-derived...
Topics
- Adjuvants, Immunologic
- Angiogenesis Inhibitors
- Antigens, CD
- B7-2 Antigen
- Cancer Vaccines
- Flow Cytometry
- Gene Transfer Techniques
- Genetic Therapy
- Genetic Vectors
- Glioma
- Granulocyte-Macrophage Colony-Stimulating Factor
- Humans
- Immunotherapy