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Article

No linkage between multiple sclerosis and the T cell receptor alpha chain locus.

Journal of the neurological sciences - 1 Jun 1994

Eoli M, Wood N W, Kellar-Wood H F, Holmans P, Clayton D, Compston D A

Abstract excerpt

Susceptibility to multiple sclerosis (MS) is genetically determined but it is thought that more than one gene contributes to development of the disease. We report a study of linkage to one candidate, the T cell receptor alpha chain locus, on chromosome 14, in affected sibling pairs. Markers with high polymorphism information contents were used to assign haplotypes identical by descent and state. Forty nine pairs...

Topics

Base Sequence
DNA
DNA Probes, HLA
DNA, Satellite
Gene Amplification
Genotype
Haplotypes
Humans
Molecular Sequence Data
Multiple Sclerosis
Pedigree
Polymorphism, Restriction Fragment Length

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Antigen, T-Cell, alpha-beta

Repetitive Sequences, Nucleic Acid

Source

Identifiers

PMID: 7931419
DOI: 10.1016/0022-510x(94)90007-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7931419-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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No linkage between multiple sclerosis and the T cell receptor alpha chain locus.PMID 7931419Read ↗

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Revisiting the T-cell receptor alpha/delta locus and possible associations with multiple sclerosis.Semantic proximity Read ↗

T-cell receptor alpha chain germline gene polymorphisms in multiple sclerosis.Semantic proximity Read ↗

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Linkage between T cell receptor genes and susceptibility to multiple sclerosis: a complex issue.Semantic proximity Read ↗

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