Article
Discordance of T-cell receptor beta-chain genes in familial multiple sclerosis.
Annals of neurology - 1 Sept 1991
Lynch S G, Rose J W, Petajan J H, Stauffer D, Kamerath C, Leppert M
Abstract excerpt
Restriction fragment length polymorphisms of the T-cell receptor beta-chain gene were studied in DNA obtained from 96 individuals from 14 multiplex families with multiple sclerosis (MS). Thirty-four family members had definite MS and two had probable MS. Five normal family members had abnormal findings on cranial magnetic resonance imaging (MRI) scans. Linkage analysis was performed using the BglII and the KpnI...
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