Article
Discordance of T-cell receptor beta-chain genes in familial multiple sclerosis.
Annals of neurology - 1 Sept 1991
Lynch S G, Rose J W, Petajan J H, Stauffer D, Kamerath C, Leppert M
Abstract excerpt
Restriction fragment length polymorphisms of the T-cell receptor beta-chain gene were studied in DNA obtained from 96 individuals from 14 multiplex families with multiple sclerosis (MS). Thirty-four family members had definite MS and two had probable MS. Five normal family members had abnormal fi...
Topics
- Alleles
- DNA
- Family
- Female
- Genetic Linkage
- Humans
- Magnetic Resonance Imaging
- Male
- Multiple Sclerosis
- Nucleic Acid Hybridization
- Odds Ratio
- Pedigree
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Receptors, Antigen, T-Cell, alpha-beta