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Article

No evidence to support CTLA-4 as a susceptibility gene in MS families: the Canadian Collaborative Study.

Journal of neuroimmunology - 1 Feb 2002

Dyment D A, Steckley J L, Willer C J, Armstrong H, Sadovnick A D, Risch N, Ebers G C

Abstract excerpt

Two polymorphisms of the CTLA-4 gene were genotyped in 232 sibling pairs affected with multiple sclerosis (MS) from 185 families. The CTLA-4 polymorphisms genotyped were a 3' untranslated (AT)(n) microsatellite and an alanine/threonine RFLP of exon 1. There was no evidence observed for linkage by either identity-by-descent (ibd) or identity-by-state (ibs) methods. A transmission disequilibrium test (TDT) was...

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Source

Identifiers

PMID: 11880164
DOI: 10.1016/s0165-5728(01)00493-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

No evidence to support CTLA-4 as a susceptibility gene in MS families: the Canadian Collaborative Study.PMID 11880164Read ↗

CTLA4 is associated with susceptibility to multiple sclerosis.Semantic proximity Read ↗

The CTLA-4 gene is associated with multiple sclerosis.Semantic proximity Read ↗

Genetic susceptibility to MS: a second stage analysis in Canadian MS families.Semantic proximity Read ↗

Variants in ST8SIA1 do not play a major role in susceptibility to multiple sclerosis in Canadian families.Semantic proximity Read ↗

No evidence of a significant role for CTLA-4 in multiple sclerosis.Semantic proximity Read ↗

HLA-DQ polymorphisms do not explain HLA class II associations with multiple sclerosis in two Canadian patient groups.Semantic proximity Read ↗

No evidence for association of CTLA-4 gene polymorphisms with the risk of developing multiple sclerosis: a meta-analysis.Semantic proximity Read ↗

Lack of association between an exon 1 CTLA-4 gene polymorphism A(49)G and multiple sclerosis in a Polish population of the Lower Silesia region.Semantic proximity Read ↗

No association between susceptibility to multiple sclerosis and HLA-DPB1 alleles in the French Canadian population.Semantic proximity Read ↗

No linkage between multiple sclerosis and the T cell receptor alpha chain locus.Semantic proximity Read ↗

Lack of association of functional CTLA4 polymorphisms with juvenile idiopathic arthritis.Semantic proximity Read ↗

Lack of association with the CD28/CTLA4/ICOS gene region among Norwegian multiple sclerosis patients.Semantic proximity Read ↗

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