Article
Susceptibility to multiple sclerosis and the immunoglobulin heavy chain variable region.
Journal of neurology - 1 Oct 1995
Wood N W, Sawcer S J, Kellar-Wood H F, Holmans P, Clayton D, Robertson N, Compston D A
Abstract excerpt
A haplotype marker consisting of three biallelic restriction fragment length polymorphism (RFLP) loci from the VH-2 variable gene family was examined in 124 families with sibling pairs concordant for multiple sclerosis, 178 unrelated patients and 159 unaffected controls to investigate the role of the immunoglobulin heavy chain gene cluster in susceptibility to multiple sclerosis. Evidence for linkage was assessed...
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