Susceptibility to multiple sclerosis and the immunoglobulin heavy chain variable region.

doi:10.1007/BF00866919

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Article

Susceptibility to multiple sclerosis and the immunoglobulin heavy chain variable region.

Journal of neurology - 1 Oct 1995

Wood N W, Sawcer S J, Kellar-Wood H F, Holmans P, Clayton D, Robertson N, Compston D A

Abstract excerpt

A haplotype marker consisting of three biallelic restriction fragment length polymorphism (RFLP) loci from the VH-2 variable gene family was examined in 124 families with sibling pairs concordant for multiple sclerosis, 178 unrelated patients and 159 unaffected controls to investigate the role of...

Topics

Alleles
Disease Susceptibility
Gene Frequency
Genes, Immunoglobulin
Genetic Linkage
Genetic Markers
Haplotypes
Humans
Likelihood Functions
Multigene Family
Multiple Sclerosis

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