Article
T-cell receptor alpha chain germline gene polymorphisms in multiple sclerosis.
Neurology - 1 Jan 1992
Hillert J, Leng C, Olerup O
Abstract excerpt
It has been proposed that genetic predisposition to multiple sclerosis (MS) and other diseases with autoimmune features is conferred by T-cell receptor (TcR) genes in addition to HLA class II genes. Although a family study has suggested linkage of susceptibility to MS to TcR genes, reports of disease associations with restriction fragment length polymorphism (RFLP)-defined alleles of TcR genes have been difficult...
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