Article
Revisiting the T-cell receptor alpha/delta locus and possible associations with multiple sclerosis.
Genes and immunity - 1 Mar 2011
Watson C T, Para A E, Lincoln M R, Ramagopalan S V, Orton S M, Morrison K M, Handunnetthi L, Handel A E, Chao M J, Morahan J, Sadovnick A D, Breden F, Ebers G C
Abstract excerpt
A role for T cells in the pathogenesis of multiple sclerosis (MS) is well supported, evidenced by myriad immunological studies, as well as the unequivocal genetic influence of the major histocompatibility complex (MHC). Despite many attempts, no convincing genetic associations have been made between T-cell receptor (TCR) gene loci and MS. However, these studies may not be definitive because of small sample sizes...
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