Article
Parental non-inherited HLA resistance alleles do not confer protection against multiple sclerosis.
Journal of neuroimmunology - 30 May 2008
Ramagopalan Sreeram V, Dyment David A, Herrera Blanca M, DeLuca Gabriele C, Lincoln Matthew R, Orton Sarah M, Handunnetthi Lahiru, Chao Michael J, Dessa Sadovnick A, Ebers George C
Abstract excerpt
Multiple sclerosis (MS) is a complex trait in which alleles at or near the class II loci HLA-DRB1 and HLA-DQB1 contribute significantly to genetic risk. HLA-DRB1*14 and DRB1*11 bearing haplotypes protect against MS and DRB1*01 and DRB1*10 interact with DRB1*15 to reduce risk of the disease. Recent work in other autoimmune diseases such as rheumatoid arthritis has suggested that maternal non-transmitted protective...
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