Article
HLA and T-cell receptor polymorphisms in Belgian multiple sclerosis patients: no evidence for disease association with the T-cell receptor.
Journal of neuroimmunology - 1 Jun 1994
Vandevyver C, Buyse I, Philippaerts L, Ghabanbasani Z, Medaer R, Carton H, Cassiman J J, Raus J
Abstract excerpt
There are compelling data to indicate that the susceptibility to multiple sclerosis (MS) is inherited, at least in part. Particular HLA genotypes may be associated with MS and recently also polymorphisms in the T-cell receptor (TCR) genes have been reported to correlate with the disease; however, these data have been difficult to confirm. We investigated the TCRA and TCRB chain genes of HLA-typed Belgian CP MS...
Topics
- Alleles
- Genotype
- HLA-DR2 Antigen
- Haplotypes
- Humans
- Multiple Sclerosis
- Polymorphism, Restriction Fragment Length
- Receptors, Antigen, T-Cell, alpha-beta