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Article

Loci predisposing to autoimmunity in MRL-Fas lpr and C57BL/6-Faslpr mice.

The Journal of clinical investigation - 1 Feb 1998

Vidal S, Kono D H, Theofilopoulos A N

Abstract excerpt

Background genes determine the incidence and severity of lymphoaccumulation and histopathologic manifestations of systemic autoimmunity in mice homozygous for the apoptosis-defective Faslpr mutation. By interval mapping of 274 F2 mice intercrossed between MRL-Faslpr (severe disease) and C57BL/6-Faslpr (minimal disease), four loci were identified with significant linkage to lymphadenopathy and/ or splenomegaly on...

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Source

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Identifiers

PMID: 9449705
DOI: 10.1172/JCI1817
PMCID: PMC508615

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Source receipt: pubmed, retrieved 7 Sept 2026.

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