Article
Loci predisposing to autoimmunity in MRL-Fas lpr and C57BL/6-Faslpr mice.
The Journal of clinical investigation - 1 Feb 1998
Vidal S, Kono D H, Theofilopoulos A N
Abstract excerpt
Background genes determine the incidence and severity of lymphoaccumulation and histopathologic manifestations of systemic autoimmunity in mice homozygous for the apoptosis-defective Faslpr mutation. By interval mapping of 274 F2 mice intercrossed between MRL-Faslpr (severe disease) and C57BL/6-F...
Topics
- Animals
- Arthritis
- Autoantibodies
- Autoimmune Diseases
- Autoimmunity
- Causality
- Chromosome Mapping
- Crosses, Genetic
- DNA
- Genetic Predisposition to Disease
- Glomerulonephritis
- Lymphatic Diseases
- Mice
- Mice, Inbred C57BL
- Mice, Inbred MRL lpr
- Pseudolymphoma
- Splenomegaly
- fas Receptor