Article
Impact of loss of NF-κB1, NF-κB2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Fas(lpr/lpr) mutant mice.
Immunology and cell biology - 1 Jan 2016
Low J T, Hughes P, Lin A, Siebenlist U, Jain R, Yaprianto K, Gray D H D, Gerondakis S, Strasser A, O'Reilly L A
Abstract excerpt
Defects in apoptosis can cause autoimmune disease. Loss-of-function mutations in the 'death receptor' FAS impair the deletion of autoreactive lymphocytes in the periphery, leading to progressive lymphadenopathy and systemic lupus erythematosus-like autoimmune disease in mice (Fas(lpr/lpr) (mice homozygous for the lymphoproliferation inducing spontaneous mutation)) and humans. The REL/nuclear factor-κB (NF-κB)...
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