Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation.

doi:10.1128/MCB.16.12.6926

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Article

Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation.

Molecular and cellular biology - 1 Dec 1996

Bazenet C E, Gelderloos J A, Kazlauskas A

Abstract excerpt

Following binding of platelet-derived growth factor (PDGF), the PDGF alpha receptor (alphaPDGFR) becomes tyrosine phosphorylated and associates with a number of signal transduction molecules, including phospholipase Cgamma-1 (PLCgamma-1), phosphatidylinositol 3-kinase (PI3K), the phosphotyrosine...

Topics

Adaptor Proteins, Signal Transducing
Animals
Cell Division
Cell Line
Fibroblasts
GRB2 Adaptor Protein
Intracellular Signaling Peptides and Proteins
Mice
Mutation
Phosphorylation
Protein Tyrosine Phosphatase, Non-Receptor Type 11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Tyrosine Phosphatase, Non-Receptor Type 6

Protein Tyrosine Phosphatases

Proteins

Receptor, Platelet-Derived Growth Factor alpha

Receptors, Platelet-Derived Growth Factor

Signal Transduction

Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 8943348
DOI: 10.1128/MCB.16.12.6926
PMCID: PMC231696

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8943348-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation.PMID 8943348Read ↗

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