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Article

The tyrosine phosphatase SHP2 is required for cell transformation by the receptor tyrosine kinase mutants FIP1L1-PDGFRα and PDGFRα D842V.

Molecular oncology - 1 May 2014

Noël Laura A, Arts Florence A, Montano-Almendras Carmen P, Cox Luk, Gielen Olga, Toffalini Federica, Marbehant Catherine Y, Cools Jan, Demoulin Jean-Baptiste

Abstract excerpt

Activated forms of the platelet derived growth factor receptor alpha (PDGFRα) have been described in various tumors, including FIP1L1-PDGFRα in patients with myeloproliferative diseases associated with hypereosinophilia and the PDGFRα(D842V) mutant in gastrointestinal stromal tumors and inflammatory fibroid polyps. To gain a better insight into the signal transduction mechanisms of PDGFRα oncogenes, we mutated...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to mRNA Cleavage and Polyadenylation Factors

Share to Oncogene Proteins, Fusion

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

Share to Receptor, Platelet-Derived Growth Factor alpha

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Identifiers

PMID: 24618081
DOI: 10.1016/j.molonc.2014.02.003
PMCID: PMC5528641

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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