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Article

Mutations to kirromycin resistance occur in the interface of domains I and III of EF-Tu.GTP.

FEBS letters - 26 Sept 1994

Abdulkarim F, Liljas L, Hughes D

Abstract excerpt

The antibiotic kirromycin inhibits protein synthesis by binding to EF-Tu and preventing its release from the ribosome after GTP hydrolysis. We have isolated and sequenced a collection of kirromycin resistant tuf mutations and identified thirteen single amino acid substitutions at seven different sites in EF-Tu. These have been mapped onto the 3D structures of EF-Tu.GTP and EF-Tu.GDP. In the active GTP form of...

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PMID: 7925958
DOI: 10.1016/0014-5793(94)00937-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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