Article
Mutations to kirromycin resistance occur in the interface of domains I and III of EF-Tu.GTP.
FEBS letters - 26 Sept 1994
Abdulkarim F, Liljas L, Hughes D
Abstract excerpt
The antibiotic kirromycin inhibits protein synthesis by binding to EF-Tu and preventing its release from the ribosome after GTP hydrolysis. We have isolated and sequenced a collection of kirromycin resistant tuf mutations and identified thirteen single amino acid substitutions at seven different...
Topics
- Amino Acids
- Anti-Bacterial Agents
- Base Sequence
- Binding Sites
- DNA Mutational Analysis
- Drug Resistance, Microbial
- Guanosine Diphosphate
- Guanosine Triphosphate
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Peptide Elongation Factor Tu