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Article

Missense substitutions lethal to essential functions of EF-Tu.

Biochimie - 1 Dec 1991

Abdulkarim F, Tuohy T M, Buckingham R H, Hughes D

Abstract excerpt

We have used a simple selection and screening method to isolate function defective mutants of EF-Tu. From 28 mutants tested, 12 different missense substitutions, individually lethal to some essential function of EF-Tu, were identified by sequencing. In addition we found a new non-lethal missense mutation. The frequency of isolation of unique mutations suggests that this method can be used to easily isolate many...

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Identifiers

PMID: 1805965
DOI: 10.1016/0300-9084(91)90178-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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