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Article

Mutant ribosomes can generate dominant kirromycin resistance.

Journal of bacteriology - 1 Jun 1991

Tubulekas I, Buckingham R H, Hughes D

Abstract excerpt

Mutations in the two genes for EF-Tu in Salmonella typhimurium and Escherichia coli, tufA and tufB, can confer resistance to the antibiotic kirromycin. Kirromycin resistance is a recessive phenotype expressed when both tuf genes are mutant. We describe a new kirromycin-resistant phenotype dominant to the effect of wild-type EF-Tu. Strains carrying a single kirromycin-resistant tuf mutation and an...

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Identifiers

PMID: 2050625
DOI: 10.1128/jb.173.12.3635-3643.1991
PMCID: PMC207990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutant ribosomes can generate dominant kirromycin resistance.PMID 2050625Read ↗

Antibiotic resistance mechanisms of mutant EF-Tu species in Escherichia coli.Semantic proximity Read ↗

The structural and functional basis for the kirromycin resistance of mutant EF-Tu species in Escherichia coli.Semantic proximity Read ↗

Mutations to kirromycin resistance occur in the interface of domains I and III of EF-Tu.GTP.Semantic proximity Read ↗

A single amino acid substitution in elongation factor Tu disrupts interaction between the ternary complex and the ribosome.Semantic proximity Read ↗

Antisuppression by mutations in elongation factor Tu.Semantic proximity Read ↗

Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors.Semantic proximity Read ↗

Mutants of EF-Tu defective in binding aminoacyl-tRNA.Semantic proximity Read ↗

Reducing ppGpp level rescues an extreme growth defect caused by mutant EF-Tu.Semantic proximity Read ↗

Phenotypic Suppression of Streptomycin Resistance by Mutations in Multiple Components of the Translation Apparatus.Semantic proximity Read ↗

Knockout of tusA confers cationic antimicrobial resistance via fur and omp genes in Escherichia coli.Semantic proximity Read ↗

Impaired in vitro kinetics of EF-Tu mutant Aa.Semantic proximity Read ↗

GE2270A-resistant mutations in elongation factor Tu allow productive aminoacyl-tRNA binding to EF-Tu.GTP.GE2270A complexes.Semantic proximity Read ↗

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