Article
Tissue-specific activating mutations of Ha- and Ki-ras oncogenes in skin, lung, and liver tumors induced in mice following transplacental exposure to DMBA.
Molecular carcinogenesis - 1 Jan 1990
Loktionov A, Hollstein M, Martel N, Galendo D, Cabral J R, Tomatis L, Yamasaki H
Abstract excerpt
Transplacental carcinogenesis represents a good model in which to study the involvement of tissue-specific oncogene activation in carcinogenesis because a single exposure to a carcinogen induces tumors at various sites. We tested tumors of the skin, liver, and lung produced in mice after transpla...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Animals
- Codon
- Female
- Fetal Diseases
- Genes, ras
- Liver Neoplasms, Experimental
- Lung Neoplasms
- Mice
- Mutation
- Organ Specificity
- Polymorphism, Restriction Fragment Length
- Pregnancy
- Skin Neoplasms