Article
The second intron of the K-ras gene contains regulatory elements associated with mouse lung tumor susceptibility.
Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 1994
Chen B, Johanson L, Wiest J S, Anderson M W, You M
Abstract excerpt
We have previously demonstrated the preferential activation of the K-ras gene from the susceptible A/J parent in lung tumors from F1 mouse hybrids. In the present study, the mechanism of this observation is further investigated. Higher levels of expression of A/J K-ras allele were detected in lun...
Topics
- Adenoma
- Alleles
- Animals
- DNA, Neoplasm
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Genetic Predisposition to Disease
- Genetic Variation
- Genotype
- Introns
- Lung Neoplasms
- Mice