Article
Genetic susceptibility to thymic lymphomas and K-ras gene mutation in mice after exposure to X-rays and N-ethyl-N-nitrosourea.
International journal of radiation biology - 1 Jun 2003
Shimada Y, Nishimura M, Kakinuma S, Ogiu T, Fujimoto H, Kubo A, Nagai J, Kobayash K, Tano K, Yoshinaga S, Bhakat K K
Abstract excerpt
PURPOSE: Ras activation is one of the major mechanisms for the development of murine thymic lymphomas by radiation and chemical carcinogens. To gain insight into the relationship between genetic susceptibility and ras gene mutation, the frequency and spectrum of ras gene mutation was examined in thymic lymphomas from susceptible and resistant mice. MATERIALS AND METHODS: K- and N-ras mutations in thymic lymphomas...
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