Article
Genetic studies on lung tumor susceptibility and histogenesis in mice.
Environmental health perspectives - 1 Jun 1991
Malkinson A M
Abstract excerpt
The probability that a mouse develops a pulmonary tumor, as well as the structure of that tumor, are dependent on several genes. Three pulmonary adenoma susceptibility (pas) genes predispose some inbred strains to develop lung tumors, even in the absence of carcinogen exposure, and cause others to be resistant. One pas gene is K-ras, which may also be overexpressed in these tumors in a mutated form capable of...
Topics
- Alleles
- Animals
- Butylated Hydroxytoluene
- Cell Division
- Cocarcinogenesis
- Cystadenoma
- Genes, ras
- Genetic Predisposition to Disease
- Glucocorticoids
- Hybridization, Genetic
- Lung Neoplasms
- Mice