Article
High frequency of K-ras mutations in spontaneous and vinyl carbamate-induced lung tumors of relatively resistant B6CF1 (C57BL/6J x BALB/cJ) mice.
Carcinogenesis - 1 May 1995
Massey T E, Devereux T R, Maronpot R R, Foley J F, Anderson M W
Abstract excerpt
The murine K-ras proto-oncogene is hypothesized to be a pulmonary adenoma susceptibility gene. This postulate is supported by the previous demonstration of a preference for mutation of the K-ras allele from the susceptible parent in lung tumors of A/J x C3H F1 mice. We have examined K-ras activation in control and vinyl carbamate (VC) (single dose 0.03 mumol/g i.p.) treated B6CF1 mice, the progeny of resistant...
Topics
- Alleles
- Animals
- Base Sequence
- Carcinogens
- Codon
- Crosses, Genetic
- DNA Primers
- Female
- Genes, ras
- Immunity, Innate
- Lung Neoplasms
- Male