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Article

Myc, Aurora Kinase A, and mutant p53(R172H) co-operate in a mouse model of metastatic skin carcinoma.

Oncogene - 24 May 2012

Torchia E C, Caulin C, Acin S, Terzian T, Kubick B J, Box N F, Roop D R

Abstract excerpt

Clinical observations, as well as data obtained from the analysis of genetically engineered mouse models, firmly established the gain-of-function (GOF) properties of certain p53 mutations. However, little is known about the underlying mechanisms. We have used two independent microarray platforms to perform a comprehensive and global analysis of tumors arising in a model of metastatic skin cancer progression,...

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Identifiers

PMID: 21963848
DOI: 10.1038/onc.2011.441
PMCID: PMC4576849

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