Article
Distinct downstream targets manifest p53-dependent pathologies in mice.
Oncogene - 3 Nov 2016
Pant V, Xiong S, Chau G, Tsai K, Shetty G, Lozano G
Abstract excerpt
Mdm2, the principal negative regulator of p53, is critical for survival, a fact clearly demonstrated by the p53-dependent death of germline or conditional mice following deletion of Mdm2. On the other hand, Mdm2 hypomorphic (Mdm2Puro/Δ7-12) or heterozygous (Mdm2+/-) mice that express either 30 or 50% of normal Mdm2 levels, respectively, are viable but present distinct phenotypes because of increased p53 activity....
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