Article
Step-wise progression in human skin carcinogenesis in vitro involves mutational inactivation of p53, rasH oncogene activation and additional chromosome loss.
Oncogene - 7 Sept 1995
Boukamp P, Peter W, Pascheberg U, Altmeier S, Fasching C, Stanbridge E J, Fusenig N E
Abstract excerpt
Two mechanisms relevant for skin carcinogenesis in man are mutational inactivation of p53 and oncogenic activation of c-rasH gene. Previously, we transfected c-rasH oncogene into human skin keratinocytes (HaCaT) with u.v.-typic mutations in both p53 alleles, which produced benign and malignant tu...
Topics
- Cell Line
- Chromosome Deletion
- Chromosomes, Human, Pair 12
- Chromosomes, Human, Pair 4
- Gene Transfer Techniques
- Genes, p53
- Genes, ras
- Humans
- Mutation
- Skin Neoplasms