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Article

Defects in transforming growth factor-β signaling cooperate with a <i>Ras</i> oncogene to cause rapid aneuploidy and malignant transformation of mouse keratinocytes

21 Dec 1999

Abstract excerpt

Genetic inactivation of the transforming growth factor-beta (TGF-beta) signaling pathway can accelerate tumor progression in the mouse epidermal model of multistage carcinogenesis. By using an in vitro model of keratinocyte transformation that parallels in vivo malignant conversion to squamous cell carcinoma, we show that v-ras(Ha) transduced primary TGF-beta1-/- keratinocytes and keratinocytes expressing a...

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PMID: 10611318
DOI: 10.1073/pnas.96.26.14949

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Source receipt: pubmed, retrieved 7 Sept 2026.

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