Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.

doi:10.1016/0092-8674(93)90461-x

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Article

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.

Cell - 10 Sept 1993

Kemp C J, Donehower L A, Bradley A, Balmain A

Abstract excerpt

The availability of p53 knockout mice generated by gene targeting has enabled us to investigate the functional role of the p53 tumor suppressor gene in initiation, promotion, and progression of carcinogenesis in vivo, using mouse skin as a model system. The number, size, and growth rate of benign...

Topics

9,10-Dimethyl-1,2-benzanthracene
Animals
Blotting, Southern
Carcinoma
DNA
Genes, p53
Genes, ras
Genotype
Heterozygote
Humans
Male
Mice
Mice, Inbred Strains
Papilloma
Skin Neoplasms
Tetradecanoylphorbol Acetate

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