Article
A PMLRARA transgene results in a retinoid-deficient phenotype associated with enhanced susceptibility to skin tumorigenesis.
Cancer research - 1 Sept 2003
Hansen Laura A, Brown Diane, Virador Victoria, Tanaka Takemi, Andreola Fausto, Strain Kathryn, Dancheck Barbara, Riley Rebeccah, Arbeit Jeffrey M, De Luca Luigi M, Kogan Scott, Yuspa Stuart H
Abstract excerpt
The construction of transgenic FVB/N mice targeting the PMLRARA fusion gene under the control of a human MRP8 promoter recapitulated the phenotype of acute promyelocytic leukemia but had the unexpected result of multiple squamous papillomas of the skin (Brown et al., PROC: Natl. Acad. Sci. USA, 94:2551-2556, 1997). In addition, transgenic MRP8-PMLRARA mice exhibited a skin phenotype characteristic of vitamin A...
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