Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53 protects against skin cancer induction by UV-B radiation.

Oncogene - 22 Jul 1999

Jiang W, Ananthaswamy H N, Muller H K, Kripke M L

Abstract excerpt

To assess the role of the p53 tumor suppressor gene in skin carcinogenesis by UV radiation, mice constitutively lacking one or both copies of the functional p53 gene were compared to wild-type mice for their susceptibility to UV carcinogenesis. Heterozygous mice showed greatly increased susceptib...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epidermis
Share to Eye Neoplasms
Share to Keratosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Melanoma, Experimental

Share to Neoplasms, Radiation-Induced

Share to Radiation Tolerance

Share to Sarcoma, Experimental

Share to Specific Pathogen-Free Organisms

Source

Identifiers

PMID: 10435637
DOI: 10.1038/sj.onc.1202789

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10435637-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53 protects against skin cancer induction by UV-B radiation.PMID 10435637Read ↗

Induction of squamous cell carcinoma in p53-deficient mice after ultraviolet irradiation.Semantic proximity Read ↗

Dose-dependent effects of UVB-induced skin carcinogenesis in hairless p53 knockout mice.Semantic proximity Read ↗

p53 mutations as a marker of skin cancer risk: comparison of UVA and UVB effects.Semantic proximity Read ↗

[Skin carcinogenesis].Semantic proximity Read ↗

Inhibition of UV-induced p53 mutations by sunscreens: implications for skin cancer prevention.Semantic proximity Read ↗

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.Semantic proximity Read ↗

Allelic losses in mouse skin tumors induced by gamma-irradiation of p53 heterozygotes.Semantic proximity Read ↗

p53 and the pathogenesis of skin cancer.Semantic proximity Read ↗

Patches of mutant p53-immunoreactive epidermal cells induced by chronic UVB Irradiation harbor the same p53 mutations as squamous cell carcinomas in the skin of hairless SKH-1 mice.Semantic proximity Read ↗

High frequency of p53 mutations in ultraviolet radiation-induced murine skin tumors: evidence for strand bias and tumor heterogeneity.Semantic proximity Read ↗

Skin tumours induced by narrowband UVB have higher frequency of p53 mutations than tumours induced by broadband UVB independent of Ogg1 genotype.Semantic proximity Read ↗

Mutant p53 reactivator SLMP53-2 hinders ultraviolet B radiation-induced skin carcinogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.