Article
The transcriptional regulatory function of p53 is essential for suppression of mouse skin carcinogenesis and can be dissociated from effects on TGF-beta-mediated growth regulation.
The Journal of pathology - 1 Oct 2009
Ponnamperuma Roshini M, King Kathryn E, Elsir Tamador, Glick Adam B, Wahl Geoffrey M, Nister Monica, Weinberg Wendy C
Abstract excerpt
Transcriptional regulation by p53 is critical for p53-mediated tumour suppression; however, p53-mediated transactivation has been dissociated from p53-mediated biological processes including apoptosis, DNA repair, and differentiation. We compared the effects of a mutant allele, p53(QS - val135), containing a double mutation in the amino-terminus abrogating transactivation activity and a modification at amino acid...
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