Accumulation of genetic alterations and progression of primary breast cancer.

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Article

Accumulation of genetic alterations and progression of primary breast cancer.

Cancer research - 1 Nov 1991

Sato T, Akiyama F, Sakamoto G, Kasumi F, Nakamura Y

Abstract excerpt

In order to detect common regions of deletion, 219 breast tumors were examined for loss of heterozygosity at several loci on chromosomes 3p, 16q, and 17 by restriction fragment length polymorphism analysis. Allelic deletions of loci on chromosomes 3p, 13q, 16q, and 17, and amplification of the erbB2 oncogene, were analyzed and compared with histopathological and clinical features. Common regions of deletion were...

Topics

Alleles
Breast
Breast Neoplasms
Carcinoma
Carcinoma, Intraductal, Noninfiltrating
Chromosome Aberrations
Chromosome Banding
Chromosome Deletion
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 16
Chromosomes, Human, Pair 17

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Chromosomes, Human, Pair 18

Chromosomes, Human, Pair 3

DNA Restriction Enzymes

Female

Humans

Polymorphism, Restriction Fragment Length

Source

Open in PubMed

Identifiers

PMID: 1682035

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1682035-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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