Allelic loss on distal chromosome 17p is associated with poor prognosis in a group of Brazilian breast cancer patients.

doi:10.1038/bjc.1994.142

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Article

Allelic loss on distal chromosome 17p is associated with poor prognosis in a group of Brazilian breast cancer patients.

British journal of cancer - 1 Apr 1994

Nagai M A, Pacheco M M, Brentani M M, Marques L A, Brentani R R, Ponder B A, Mulligan L M

Abstract excerpt

We examined loss of heterozygosity (LOH) for two loci on chromosome 17p (D17S5 and TP53), and erbB-2 gene amplification, in primary breast cancers from 67 Brazilian patients. We identified two distinct regions of LOH on chromosome 17p, one spanning TP53 and the other a more telomeric region (D17S5). Based on a short-term follow-up, Kaplan-Meier analyses of patients' disease-free survival showed that patients with...

Topics

Adult
Aged
Aged, 80 and over
Alleles
Brazil
Breast Neoplasms
Carcinoma, Ductal, Breast
Carcinoma, Lobular
Carcinoma, Medullary
Chromosomes, Human, Pair 17
DNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

ErbB Receptors

Female

Gene Amplification

Gene Deletion

Genes, Tumor Suppressor

Genes, p53

Heterozygote

Source

Open in PubMed Open full text

Identifiers

PMID: 7908218
DOI: 10.1038/bjc.1994.142
PMCID: PMC1968822

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7908218-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Allelic loss on distal chromosome 17p is associated with poor prognosis in a group of Brazilian breast cancer patients.PMID 7908218Read ↗

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