Point mutations of the N‐<i>ras</i> gene in the blood plasma DNA of patients with myelodysplastic syndrome or acute myelogenous leukaemia

Abstract excerpt

Oncogene mutations are frequently found in several tumour types and, among these, point mutations of the ras gene are particularly significant. A predominance of N-ras mutations has been found in the bone marrow DNA of patients with myelodysplastic syndrome (MDS) or acute myelogenous leukaemia (AML). On the other hand, increased levels of plasma DNA have previously been observed in patients suffering from various...

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