Article
Ha-ras hypervariable alleles in myelodysplasia.
Nature - 1 Jan 2000
Thein S L, Oscier D G, Flint J, Wainscoat J S
Abstract excerpt
The somatic mutation of one of the ras oncogenes is now considered to be a critical step in the pathogenesis of many tumours. Circumstantial evidence also suggests that some individuals may be genetically predisposed to malignancy and a general method used to analyse such disease susceptibility is the study of restriction fragment length polymorphisms (RFLPs) at particular loci. The Harvey ras (Ha-ras) locus...
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