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Article

Detection of allele-specific expression of N-RAS oncogenes in human leukaemia cells.

British journal of haematology - 1 Jul 1992

Lübbert M, Mertelsmann R, Herrmann F

Abstract excerpt

We report analysis of allele-specific expression of N-RAS transcripts in myeloid leukaemic cells and cell lines. Expression was assessed by an assay of reverse-transcription/PCR combined with differential hybridization with mutation-specific oligonucleotides. In cells from all patients with acute myeloid leukaemia (AML) and in myeloid cell lines HL-60 and THP-1, expression of both the wild-type allele and the...

Topics

Acute Disease
Alleles
Base Sequence
DNA, Neoplasm
Gene Expression
Gene Expression Regulation, Neoplastic
Genes, ras
Humans
Immunoblotting
Leukemia, Myeloid
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotides

Polymerase Chain Reaction

Transcription, Genetic

Source

Identifiers

PMID: 1390209
DOI: 10.1111/j.1365-2141.1992.tb08241.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1390209-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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