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Article

The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement.

Immunology today - 1 Aug 1994

Chang B, Casali P

Abstract excerpt

The variable (V) genes of antigen-selected antibodies are known to exhibit a higher frequency of amino acid replacement mutations in the sequences encoding the antigen-contacting complementarity-determining regions (CDRs) than in those encoding the 'structural' framework regions (FRs). Here, Bernard Chang and Paolo Casali analyse the impact of regional differences in the codon composition of human germline Ig VH...

Topics

Amino Acid Sequence
Amino Acids
Base Sequence
Genes, Immunoglobulin
Humans
Immunoglobulin Variable Region
Molecular Sequence Data
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7916950
DOI: 10.1016/0167-5699(94)90175-9
PMCID: PMC4665105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7916950-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement.PMID 7916950Read ↗

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