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Article

Differences in potential for amino acid change after mutation reveals distinct strategies for kappa and lambda light-chain variation.

Proceedings of the National Academy of Sciences of the United States of America - 24 Oct 2006

Hershberg Uri, Shlomchik Mark J

Abstract excerpt

B cells generate varied yet functional clones under high rates of mutation of their V genes. It has been proposed that as a result of the opposing demands of diversification and preservation of integrity, the V genes of heavy and light chains have evolved to overexpress codons prone to amino acid change in their complementarity determining regions (CDR) compared with the framework (FW) regions. We have analyzed...

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Identifiers

PMID: 17038496
DOI: 10.1073/pnas.0607581103
PMCID: PMC1635110

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Source receipt: pubmed, retrieved 7 Sept 2026.

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