A statistical examination of hypervariability in complementarity-determining regions of immunoglobulins.

doi:10.1016/1055-7903(92)90006-3

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Article

A statistical examination of hypervariability in complementarity-determining regions of immunoglobulins.

Molecular phylogenetics and evolution - 1 Dec 1992

Ohta T

Abstract excerpt

To determine the relative importance of gene conversion followed by natural selection and of natural selection for point mutation in generating variability in immunoglobulins, the numbers of synonymous and nonsynonymous substitutions in immunoglobulin sequences of various subgroups were estimated...

Topics

Animals
Antibody Diversity
Biometry
Gene Conversion
Gene Rearrangement
Genes, Immunoglobulin
Genetic Complementation Test
Genetic Variation
Humans
Mice
Models, Genetic
Point Mutation
Rabbits
Selection, Genetic
Species Specificity

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