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Article

A statistical examination of hypervariability in complementarity-determining regions of immunoglobulins.

Molecular phylogenetics and evolution - 1 Dec 1992

Ohta T

Abstract excerpt

To determine the relative importance of gene conversion followed by natural selection and of natural selection for point mutation in generating variability in immunoglobulins, the numbers of synonymous and nonsynonymous substitutions in immunoglobulin sequences of various subgroups were estimated for complementarity-determining regions (CDRs) and for framework regions (FRs). Both the number of synonymous...

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PMID: 1342946
DOI: 10.1016/1055-7903(92)90006-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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