Article
Somatic hypermutation targeting is influenced by location within the immunoglobulin V region.
Molecular immunology - 1 Jul 2011
Cohen Reuma Magori, Kleinstein Steven H, Louzoun Yoram
Abstract excerpt
The observed mutation pattern in immunoglobulin (Ig) V genes from peripheral B cells is influenced by several mechanisms, including the targeting of AID to specific DNA motifs, negative selection of B cells unable to express Ig receptor, and positive selection of B cells that carry affinity-increasing mutations. These influences, combined with biased codon usage, produce the well-known pattern of increased...
Topics
- Animals
- B-Lymphocytes
- Base Sequence
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Variable Region
- Mice
- Models, Genetic
- Models, Statistical
- Mutation
- Sequence Analysis, DNA