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Article

Somatic hypermutation targeting is influenced by location within the immunoglobulin V region.

Molecular immunology - 1 Jul 2011

Cohen Reuma Magori, Kleinstein Steven H, Louzoun Yoram

Abstract excerpt

The observed mutation pattern in immunoglobulin (Ig) V genes from peripheral B cells is influenced by several mechanisms, including the targeting of AID to specific DNA motifs, negative selection of B cells unable to express Ig receptor, and positive selection of B cells that carry affinity-increasing mutations. These influences, combined with biased codon usage, produce the well-known pattern of increased...

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Share to B-Lymphocytes
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Share to Genes, Immunoglobulin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin Variable Region

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Share to Sequence Analysis, DNA

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Identifiers

PMID: 21592579
DOI: 10.1016/j.molimm.2011.04.002
PMCID: PMC3109224

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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